Distinguishing rotamers in N-trifluoroacetyl-3-benzazepine derivatives.
نویسندگان
چکیده
This paper provides the full (13) C NMR assignments for the trifluoroacetamides of five potentially appetite-reducing 5-HT2C benzazepine receptor agonists and two open-ring synthetic precursors. These compounds exist in solution as mixtures of two rotamers for each of which the (13) C NMR signals have now been assigned with the assistance of 2D NMR experiments and the carbonyl-induced shifts of the neighboring (13) CH2 resonances and long-range (13) C/(19) F couplings.
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عنوان ژورنال:
- Magnetic resonance in chemistry : MRC
دوره 54 7 شماره
صفحات -
تاریخ انتشار 2016